Boeing Research & Technology The Licklider Transmission Protocol (LTP) provides a reliable datagram convergence layer for the Delay/Disruption Tolerant Networking (DTN) Bundle Protocol. In common practice, LTP is often configured over UDP/IP sockets and inherits its maximum segment size from the maximum-sized UDP/IP datagram, however when this size exceeds the path maximum transmission unit a service known as IP fragmentation must be engaged. This document discusses performance maximization implications of LTP interactions with large packet sizes and IP fragmentation.