Iron Triangle Trace for Longevity (ITT-L): A PACR Application Payload Format for Gene-Level Longevity Data
draft-aevum-itt-l-00
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| Document | Type | Active Internet-Draft (individual) | |
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| Author | TSOI KWAI LAP | ||
| Last updated | 2026-05-18 | ||
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draft-aevum-itt-l-00
Individual Submission K. Tsoi
Internet-Draft Aevum Network
Intended status: Informational 15 May 2026
Expires: 16 November 2026
Iron Triangle Trace for Longevity (ITT-L): A PACR Application Payload
Format for Gene-Level Longevity Data
draft-aevum-itt-l-00
Abstract
This document defines Iron Triangle Trace for Longevity (ITT-L), a
domain-specific Application Payload Format carried within the PACR
(Physical and Causal Auditable Record) envelope. Each ITT-L record
binds four measurement facets — gene, mechanism, drug/metabolite, and
epigenetic — into a single independently-citable asset with causal
predecessor chain (Π) integrity provided by the PACR transport layer.
ITT-L is NOT a standalone protocol; it is a payload format that
leverages PACR for physical proof (Λ, Landauer cost) and causal
ordering (Π chain), and AgentCard for service identity.
Status of This Memo
This Internet-Draft is submitted in full conformance with the
provisions of BCP 78 and BCP 79.
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This Internet-Draft will expire on 16 November 2026.
Copyright Notice
Copyright (c) 2026 IETF Trust and the persons identified as the
document authors. All rights reserved.
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This document is subject to BCP 78 and the IETF Trust's Legal
Provisions Relating to IETF Documents (https://trustee.ietf.org/
license-info) in effect on the date of publication of this document.
Please review these documents carefully, as they describe your rights
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Table of Contents
1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . 2
2. Terminology . . . . . . . . . . . . . . . . . . . . . . . . . 3
3. Payload Structure . . . . . . . . . . . . . . . . . . . . . . 3
3.1. Required Fields . . . . . . . . . . . . . . . . . . . . . 3
3.2. Optional Fields . . . . . . . . . . . . . . . . . . . . . 4
4. Coupling Edges . . . . . . . . . . . . . . . . . . . . . . . 4
5. Falsifiability Considerations . . . . . . . . . . . . . . . . 5
6. Security Considerations . . . . . . . . . . . . . . . . . . . 5
7. IANA Considerations . . . . . . . . . . . . . . . . . . . . . 5
8. Normative References . . . . . . . . . . . . . . . . . . . . 6
9. Informative References . . . . . . . . . . . . . . . . . . . 6
Author's Address . . . . . . . . . . . . . . . . . . . . . . . . 7
1. Introduction
Longevity research produces data across multiple measurement layers:
genomic variants, proteomic drug targets, metabolic pathway
participants, and epigenetic clock markers. These data are typically
stored in heterogeneous databases with no common citation format,
making cross-layer validation and third-party reproducibility
difficult.
ITT-L addresses this by defining a standardized JSON payload format
that binds all four measurement layers per gene into a single record.
Each ITT-L record is carried inside a PACR envelope, which provides:
* *ι* (CausalId): 128-bit unique record identity
* *Π* (predecessor chain): causal ordering of DoD validation steps
* *Λ* (Landauer cost): physical proof that record generation
consumed real computational resources
* *Ω* (resource triple): energy, time, and space consumed
* *Γ* (cognitive split): statistical complexity vs. entropy rate
(S_T/H_T)
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ITT-L is complementary to [I-D.draft-aevum-agentcard], which declares
agent identity and capabilities, and
[I-D.draft-aevum-causal-intervention-record], which defines the PACR
transport envelope.
2. Terminology
The key words "MUST", "MUST NOT", "REQUIRED", "SHALL", "SHALL NOT",
"SHOULD", "SHOULD NOT", "RECOMMENDED", "NOT RECOMMENDED", "MAY", and
"OPTIONAL" in this document are to be interpreted as described in BCP
14 [RFC2119] [RFC8174] when, and only when, they appear in all
capitals, as shown here.
ITT-L Record: One Iron Triangle Trace for Longevity payload, carried
inside the body(P) field of a PACR envelope.
Facet: One of the four measurement dimensions: gene_facet,
mechanism_facet, drug_metabolite_facet, or epigenetic_facet.
Coupling Edge: A measurement of information fidelity between two
facets (e.g., gene→protein translation fidelity). May be
unmeasured (honest marker).
H_ITT_gene: A composite health index per gene, ∈ [0,1], computed as
the product of facet completeness, facet consistency, and edge
factor.
DoD (Definition of Done): A 7-condition validation gate (D1-D7)
applied to each gene before ITT-L record generation.
3. Payload Structure
An ITT-L payload is a JSON object carried in the body(P) field of a
PACR Application Payload. The JSON Schema is defined at
https://eon.aevum.network/itt-l-schema-v1.json.
3.1. Required Fields
The following fields MUST be present in every ITT-L payload:
* record_type: MUST be the string "iron_triangle_trace_l".
* schema_version: MUST be "1.0".
* gene_facet: object with gene_symbol (string) and causal_score
(number).
* mechanism_facet: object with KEGG/Reactome pathway data and a
mechanism_partial boolean (honest marker).
* drug_metabolite_facet: object with DrugBank entries, AlphaFold
pLDDT, and metabolites.
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* coupling_edges: object with three sub-objects (gene_protein,
protein_epi, epi_gene), each containing value (number or null),
status (enum: unmeasured, estimated, measured,
blocked_external_data), and source (string or null).
* h_itt_gene: number ∈ [0,1], computed as facet_completeness ×
facet_consistency × (1 + edges_measured/3) / 2. This formula is
frozen in v1.0.
3.2. Optional Fields
The following fields MAY be present:
* epigenetic_facet: object with EPI-score, Horvath CpG count, and
epigenetic modifier status.
* discovery_class: enum "novel" | "drug_ready", indicating the DoD
track that produced this record.
* auto_discovered: boolean indicating whether the record was
generated by the ITT-grower daemon rather than human curation.
4. Coupling Edges
The three coupling edges map to the iron triangle framework described
in [I-D.veneter]: genome, proteome, and epigenome form three
vertices; the edges measure information flow fidelity between them.
gene_protein: Translation fidelity — mRNA-to-protein correlation.
Measurement operator: Ribosome Profiling + proteomics Pearson r
(Frobenius norm).
protein_epi: Modification fidelity — SIRT1 activity × DNMT3A
methylation maintenance rate, normalized to [0,1].
epi_gene: Regulatory fidelity — ATAC-seq open chromatin peak overlap
at FOXO3 binding sites.
In ITT-L v1.0, all coupling edges default to status "unmeasured" —
this is an honest marker, not a data gap. Edges transition to
"measured" when the corresponding measurement operator produces a
value. The edge_factor component of H_ITT_gene increases from 0.5
(all unmeasured) toward 1.0 (all measured), providing a built-in
incentive for edge measurement without penalizing records that
legitimately lack measurement data.
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5. Falsifiability Considerations
ITT-L is designed as an engineering protocol that also supports
scientific falsifiability. Four falsifiable predictions are defined
in the companion Falsifiability Manifest (EON-ITT-L-FALSIFIABILITY-
MANIFEST.md):
1. *F1 (Intervention Effect)*: novel 6/6 genes show Horvath Δage ≤
-3 years after intervention. Falsified if ≥30 wet-lab records
show otherwise.
2. *F2 (Coupling Prediction)*: high protein_epi genes show greater
intervention ROI (r ≥ 0.2). Falsified if correlation is below
threshold.
3. *F3 (H_ITT Predictive Power)*: genes with h_itt_gene ≥ 0.7 are
adopted as clinical trial targets at a higher rate than baseline.
Falsified if p ≥ 0.05.
4. *F4 (Facet Completeness)*: complete 4-facet genes show higher D7
wet-lab pass rates than incomplete genes. Falsified if p ≥ 0.05.
6. Security Considerations
ITT-L does not introduce new security considerations beyond those
already described in the PACR transport specification
[I-D.draft-aevum-causal-intervention-record]. The following
considerations apply:
* Λ (Landauer cost) provides a physical lower bound on forgery cost
— any attacker attempting to inject fraudulent ITT-L records MUST
spend at least LANDAUER_JOULES_300K (≈2.87 × 10⁻²¹ J) per bit of
erased information. While individually small, this cost scales
linearly with record size and count, making bulk forgery
detectable through energy anomaly.
* The Π (predecessor) chain ensures that any ITT-L record's causal
ancestry can be independently verified without trusting the EON
service.
* Sensitive gene data (e.g., rare variant information) is public
research data derived from UK Biobank, GTEx, and PubMed. No
personally identifiable information is stored in ITT-L records.
7. IANA Considerations
This document requests the registration of the following media type:
Type name: application
Subtype name: eon-itt-l+json
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Required parameters: N/A
Optional parameters: N/A
Encoding considerations: binary (UTF-8 JSON)
Security considerations: See Security Considerations (Section 6) of
this document.
Interoperability considerations: Payload MUST validate against the
JSON Schema at https://eon.aevum.network/itt-l-schema-v1.json
Published specification: This document
Applications that use this media type: EON Longevity Target
Discovery system
Fragment identifier considerations: N/A
Restrictions on usage: N/A
Provisional registration: Yes
8. Normative References
[RFC2119] Bradner, S., "Key words for use in RFCs to Indicate
Requirement Levels", March 1997,
<https://www.rfc-editor.org/info/rfc2119>.
[RFC8174] Leiba, B., "Ambiguity of Uppercase vs Lowercase in RFC
2119 Key Words", May 2017,
<https://www.rfc-editor.org/info/rfc8174>.
9. Informative References
[I-D.draft-aevum-agentcard]
Tsoi, K., "AgentCard: A Framework-Neutral Identity and
Capability Declaration Format", 23 April 2026,
<https://datatracker.ietf.org/doc/draft-aevum-agentcard/>.
[I-D.draft-aevum-causal-intervention-record]
Tsoi, K., "Causal Intervention Record (PACR): A Physics-
Grounded Audit Trail for Agent Actions", 26 April 2026,
<https://datatracker.ietf.org/doc/draft-aevum-causal-
intervention-record/>.
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[I-D.veneter]
Venter, C., "Iron Triangle of Longevity Research", April
2026, <https://github.com/kwailapt/EON>.
Author's Address
Kwai Lap Tsoi
Aevum Network
Email: kwailapt@gmail.com
URI: https://github.com/kwailapt/EON
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